| Date | Opponent | Result | Location | Caption |
|---|---|---|---|---|
| 8/27/2021 |
vs
Johnston #111
|
L 22-28 | Johnston High School | |
| 9/3/2021 |
vs
Waterloo West #206
|
W 52-14 | UNI-Dome | |
| 9/10/2021 |
vs
Prairie #62
|
W 24-21 | Cedar Rapids Prairie High School | |
| 9/17/2021 |
vs
Ankeny Centennial #98
|
W 28-14 | UNI-Dome | |
| 9/24/2021 |
@
Muscatine #264
|
W 42-7 | Muscatine High School | Homecoming |
| 10/1/2021 |
@
Cedar Rapids Kennedy #53
|
L 14-42 | Kingston Stadium | |
| 10/8/2021 |
vs
Dubuque Hempstead #175
|
W 42-28 | UNI-Dome | Homecoming |
| 10/15/2021 |
@
Bettendorf #103
|
L 0-28 | Bettendorf High School | |
| 10/22/2021 |
vs
Dubuque Senior #126
|
W 37-21 | UNI-Dome | |
| 10/29/2021 |
vs
Pleasant Valley #65
|
L 14-42 | Pleasant Valley High School | 5A - First Round |
