| Date | Opponent | Result | Location | Caption |
|---|---|---|---|---|
| 8/27/2021 |
vs
Winterset #28
|
L 3-26 | Carlisle High School | |
| 9/3/2021 |
@
Lewis Central #9
|
L 22-70 | Lewis Central High School | |
| 9/10/2021 |
@
Knoxville #289
|
W 62-6 | Knoxville High School | |
| 9/17/2021 |
vs
Des Moines Lincoln #104
|
W 35-6 | Carlisle High School | Homecoming |
| 9/24/2021 |
@
Bondurant-Farrar #34
|
L 29-39 | Bondurant-Farrar High School | Youth Cheer |
| 10/1/2021 |
vs
Boone #233
|
W 41-18 | Carlisle High School | |
| 10/8/2021 |
vs
Indianola #22
|
L 14-38 | Carlisle High School | |
| 10/15/2021 |
@
Norwalk #58
|
W 21-14 | Norwalk High School | |
| 10/22/2021 |
vs
Perry #325
|
W 70-6 | Carlisle High School | Senior Night |
| 10/29/2021 |
vs
Indianola #22
|
L 0-41 | Indianola Stadium | 4A - First Round |
