| Date | Opponent | Result | Location | Caption |
|---|---|---|---|---|
| 8/27/2021 |
@
Sisseton #146
|
W 38-0 | Sisseton High School | |
| 9/3/2021 |
@
Chamberlain #126
|
W 28-6 | Chamberlain High School | Military/First Responders Night |
| 9/10/2021 |
vs
Madison #6
|
L 26-37 | DakotaDome | Vermillion Homecoming |
| 9/17/2021 |
@
Canton #33
|
L 7-42 | Canton High School | Homecoming |
| 9/24/2021 |
@
Lennox #67
|
W 21-7 | Lennox Football/Track Complex | Homecoming |
| 10/1/2021 |
@
Dell Rapids #45
|
W 33-28 | Dell Rapids High School | |
| 10/8/2021 |
vs
West Central #65
|
W 28-26 | DakotaDome | |
| 10/15/2021 |
vs
Tri-Valley #63
|
L 13-20 | DakotaDome | Senior Night |
| 10/21/2021 |
vs
Dakota Valley #119
|
W 34-6 | DakotaDome | |
| 10/28/2021 |
vs
Tri-Valley #63
|
W 21-7 | DakotaDome | Class 11A - State Quarterfinal |
| 11/5/2021 |
vs
Milbank #48
|
L 0-24 | DakotaDome | Class 11A - State Semifinal |
