| Date | Opponent | Result | Location | Caption |
|---|---|---|---|---|
| 8/27/2021 |
@
Milbank #48
|
L 0-52 | A.B. Campbell Stadium | |
| 9/3/2021 |
vs
Vermillion #53
|
L 6-28 | Chamberlain High School | Military/First Responders Night |
| 9/10/2021 |
@
Dell Rapids #45
|
L 14-42 | Dell Rapids High School | |
| 9/17/2021 |
vs
Tri-Valley #63
|
L 0-19 | Chamberlain High School | Parent's Night |
| 9/24/2021 |
vs
Belle Fourche #118
|
L 14-28 | Belle Fourche High School | 7:00 CST |
| 10/2/2021 |
vs
Sisseton #146
|
W 48-0 | Chamberlain High School | |
| 10/8/2021 |
vs
Canton #33
|
L 7-35 | Chamberlain High School | Home Coming |
| 10/15/2021 |
@
Lennox #67
|
L 0-38 | Lennox Football/Track Complex | |
| 10/21/2021 |
@
Custer #134
|
W 29-26 | Custer Football Field | Senior Night |
