| Date | Opponent | Result | Location | Caption |
|---|---|---|---|---|
| 8/27/2021 | @ Omaha Nation, NE #50 | L 36-42 | Lower Brule High School | |
| 9/3/2021 |
@
Mahpíya Lúta #25
|
L 6-42 | Red Cloud Indian School | |
| 9/10/2021 |
@
Marty #123
|
W 58-0 | Marty Indian School | |
| 9/17/2021 |
vs
Takini #136
|
W 65-8 | Lower Brule High School | Homecoming |
| 10/1/2021 |
vs
McLaughlin #42
|
W 30-22 | Lower Brule High School | |
| 10/8/2021 |
@
Crow Creek #101
|
W 56-14 | Stephan | |
| 10/16/2021 |
vs
Todd County #22
|
L 42-44 | Lower Brule High School | Parents Night |
| 10/22/2021 |
@
Crazy Horse #122
|
W 1-0 | Crazy Horse School | FORFEIT |
| 10/29/2021 |
vs
Tiospa Zina #12
|
L 16-38 | Tiospa Zina Tribal School | All Nations B - State Semifinal |
