| Date | Opponent | Result | Location | Caption |
|---|---|---|---|---|
| 8/27/2021 |
vs
West Sioux #16
|
L 21-73 | Hartley-Melvin-Sanborn High School | HMS Partners in Education Tailgate |
| 9/3/2021 |
vs
Gehlen Catholic #145
|
W 44-33 | Hartley-Melvin-Sanborn High School | |
| 9/10/2021 |
@
South O'Brien #115
|
W 26-0 | South O'Brien High School | |
| 9/17/2021 |
@
MMCRU #290
|
W 66-14 | MMCRU High School | |
| 9/24/2021 |
vs
Alta-Aurelia #169
|
W 66-22 | Hartley-Melvin-Sanborn High School | Senior Night |
| 10/1/2021 |
@
West Hancock #7
|
L 6-20 | West Hancock High School | Week 6 Non-District |
| 10/8/2021 |
vs
Hinton #260
|
W 61-13 | Hartley-Melvin-Sanborn High School | Homecoming |
| 10/15/2021 |
vs
Akron-Westfield #197
|
W 50-13 | Akron Westfield School | |
| 10/22/2021 |
vs
Tri-Center #106
|
W 70-54 | Hartley-Melvin-Sanborn High School HMS - Peterson Field | A - First Round |
| 10/29/2021 |
vs
North Butler #79
|
W 26-7 | Hartley-Melvin-Sanborn High School HMS - Peterson Field | A - Second Round |
| 11/5/2021 |
vs
West Hancock #7
|
L 0-27 | West Hancock High School | A - Quarterfinals |
