| Date | Opponent | Result | Location | Caption |
|---|---|---|---|---|
| 11/23/2021 | @ Quincy Notre Dame | L 47-60 | Quincy Notre Dame High School | |
| 11/30/2021 |
vs
Iowa City Liberty #53
|
L 50-61 | Liberty High School | |
| 12/3/2021 |
@
Burlington #339
|
W 60-17 | Burlington High School | |
| 12/4/2021 |
@
Assumption #65
|
L 51-59 | Assumption High School | Non Conference Game |
| 12/10/2021 |
vs
Mount Pleasant #155
|
W 73-40 | Keokuk HS - Wright Fieldhouse | |
| 12/13/2021 | @ Clark County | W 59-21 | ||
| 12/17/2021 |
vs
Fort Madison #130
|
W 50-46 | Keokuk HS - Wright Fieldhouse | |
| 12/20/2021 |
@
Fairfield #144
|
W 54-46 | Fairfield High School | |
| 1/3/2022 |
vs
West Burlington #168
|
W 76-34 | West Burlington High School | |
| 1/7/2022 |
vs
Burlington #339
|
W 62-18 | Keokuk HS - Wright Fieldhouse | |
| 1/11/2022 |
@
Washington #284
|
W 64-18 | Washington High School | PTO Silent Auction |
| 1/17/2022 | vs Midwest Central | W 57-39 | ||
| 1/18/2022 |
vs
Washington #284
|
W 63-22 | Keokuk HS - Wright Fieldhouse | |
| 1/21/2022 |
@
Fort Madison #130
|
W 53-40 | Fort Madison High School | |
| 1/25/2022 | vs West Hancock | W 59-29 | Keokuk HS - Wright Fieldhouse | |
| 1/28/2022 |
@
Mount Pleasant #155
|
W 85-79 | Mt Pleasant High School | |
| 1/29/2022 |
vs
Central Lee #180
|
W 63-29 | Keokuk HS - Wright Fieldhouse | Green Out Game |
| 2/1/2022 | @ Highland | W 54-27 | ||
| 2/4/2022 |
vs
Fairfield #144
|
W 51-42 | Keokuk HS - Wright Fieldhouse | |
| 2/8/2022 | @ Canton | W 70-47 | ||
| 2/19/2022 |
vs
Mount Pleasant #155
|
W 63-42 | Keokuk HS - Wright Fieldhouse | Class 4A Region 2 Semifinal |
| 2/22/2022 |
vs
Xavier #16
|
L 36-58 | Xavier High School | Class 4A Region 2 Championship |
