| Date | Opponent | Result | Location | Caption |
|---|---|---|---|---|
| 8/20/2021 |
vs
Aberdeen Roncalli #73
|
L 10-31 | Swisher Field | 4:00 Mountain Time |
| 8/27/2021 |
vs
Mobridge-Pollock #105
|
W 21-0 | St. Thomas More High School | 6:00 PM MST |
| 9/3/2021 |
vs
Hot Springs #97
|
W 14-0 | Woodward Field | |
| 9/11/2021 |
vs
Winner #3
|
L 7-54 | St. Thomas More High School | Hall of Fame - Game Saturday at 2:00 PM Mountain Time |
| 9/24/2021 |
vs
Douglas #143
|
W 36-0 | St. Thomas More High School | Homecoming |
| 10/1/2021 |
@
Spearfish #104
|
W 22-21 | Lyle Hare Stadium | Senior Night for Golf, XC, Tennis |
| 10/8/2021 |
vs
Belle Fourche #118
|
W 35-13 | St. Thomas More High School | Cancer Awareness Night |
| 10/15/2021 |
@
Sturgis Brown #102
|
L 22-29 | O'Harra Stadium | Senior Night - O'Harra Stadium |
| 10/21/2021 |
@
Elk Point-Jefferson #18
|
L 28-56 | Elk Point-Jefferson High School | Class 11B - State First Round |
